High-resolution mapping reveals hundreds of genetic incompatibilities in hybridizing fish species

TitelHigh-resolution mapping reveals hundreds of genetic incompatibilities in hybridizing fish species
MedientypJournal Article
Jahr der Veröffentlichung2014
AutorenSchumer, M., R. Cui, D. L. Powell, R. Dresner, G. G. Rosenthal, and P. Andolfatto
ZweitautorenMcVean, G.
Schlüsselwörtergenetic incompatibility, hybrid fitness, hybridization, speciation

Hybridization is increasingly being recognized as a common process in both animal and plant species. Negative epistatic interactions between genes from different parental genomes decrease the fitness of hybrids and can limit gene flow between species. However, little is known about the number and genome-wide distribution of genetic incompatibilities separating species. To detect interacting genes, we perform a high-resolution genome scan for linkage disequilibrium between unlinked genomic regions in naturally occurring hybrid populations of swordtail fish. We estimate that hundreds of pairs of genomic regions contribute to reproductive isolation between these species, despite them being recently diverged. Many of these incompatibilities are likely the result of natural or sexual selection on hybrids, since intrinsic isolation is known to be weak. Patterns of genomic divergence at these regions imply that genetic incompatibilities play a significant role in limiting gene flow even in young species.


Ich kenne nichts Ärmeres unter der Sonn' als euch Götter! Ihr nähret kümmerlich von Opfersteuern und Gebetshauch eure Majestät und darbtet, wären nicht Kinder und Bettler hoffnungsvolle Toren. {Goethe, Prometheus}